Inflammatory Disorders of Bone

by Melissa Phua

1) Osteomyelitis is the inflammation of bone and marrow.
2) E. Coli is the main cause for pyogenic osteomyelitis because it has receptors for bone matrix components.
3) Osteomyelitis in children mainly occurs in metaphysis.
4) Sequestrum is a dead piece of bone formed due to segmental bone necrosis.
5) In adults, location of osteomyelitis is mainly in the metaphysis and epiphysis.
6) Chronic inflammatory cells become more numerous at the site of infection after a week.
7) Reactive new bone which sleeves around the segment of devitalized infected bone is also known as involucrum.
8) Brodie abscess always occur after the acute stage of osteomyelitis.
9) Rupture of periosteum leads to formation of draining sinuses and soft tissue abscesses.
10) Sinuses formed will drain their pus to the skin surface via cloacae.
11) Cytokines released due to inflammatory reaction cause increase osteoblastic activity.
12) Haematogenous osteomyelitis presents as chronic systemic illness.
13) Vertebral osteomyelitis causes a dull continuous back pain which worsens upon straining.
14) Osteomyelitis can be treated by surgical drainage and antibiotics.
15) Biopsy and bone cultures are used to identify the pathogen causing the disease.
16) Chronic osteomyelitis always lead to sarcoma of he infected bone.
17) Chronic osteomyelitis occurs when there is delay in diagnosis and extensive bone disease.
17) Tuberculous osteomyelitis only spreads through direct extension and haematogenous spread.
18) The bony infection due to tuberculous osteomyelitis always come with other manifestation of the disease and is never solitary.
19) Chronic osteomyelitis occurs due to inadequate antibiotic therapy and weakened host defense.
20) Pott disease affects the thoracic and lumbar vertebrae.
21) Pyogenic osteomyelitis is more destructive and resistant compared to tuberculous osteomyelitis.
22) Pott disease involves the destruction of a single vertebra.
23) Other complications of tuberculous osteomyelitis involve the formation of psoas abscess and amyloidosis.
24) Blood culture and x ray can be used to diagnose osteomyelitis.
25) Tuberculous osteomyelitis can cause only solitary lesions.