1.
This drug control the acid release
in stomach and produce mucus to protect the line of stomach
|
a)
Prostaglandin
|
T
|
|
b)
Prostacyclin
|
F
|
|
c)
Thromboxane A2
|
F
|
|
d)
Leukotriene
|
F
|
2.
These are the non selective COX
inhibitors
|
a)
Aspirin
|
T
|
|
b)
Paracetamol
|
T
|
|
c)
Piroxicam
|
T
|
|
d)
rofecoxib
|
F
|
3.
Aspirin
|
a)
Reversibly acetylates COX
|
F
|
|
b)
Irreversibly acetylates COX
|
T
|
|
c)
Leads to inhibition of
prostaglandin
|
T
|
|
d)
Can cause asthma, nephritis,
gastric ulcer
|
T
|
4.
Aspirin, regarding to
pharmacological action
|
a)
Converted to 5-FdUMP to inhibit thymidylate kinase
|
F
|
|
b)
Produce anticoagulant effect
|
T
|
|
c)
It inhibit thromboxane A2
production
|
T
|
|
d)
It acetylate cyclooxygenase
enzyme
|
T
|
5.
This drug is use for treatment of
gout, rheumatic fever, osteoarthritis
|
a)
Paracetamol
|
F
|
|
b)
Metothrexate
|
F
|
|
c)
Aspirin
|
T
|
|
d)
Ketoconazole
|
F
|
6.
Regarding acetaminophen
|
a)
It bind with ergosterol
|
F
|
|
b)
It is suitable alternative for
aspirin
|
T
|
|
c)
It gives less toxicity to liver
|
F
|
|
d)
It inhibit prostaglandin
synthesis
|
T
|
7.
Ibuprofen
|
a)
It is potent anti inflammatory
drug
|
T
|
|
b)
It is the only drug use for
parenteral administration
|
F
|
|
c)
It is the safest drug and least
expensive
|
T
|
|
d)
It is 20 times potent inhibitor
of COX than aspirin
|
F
|
8.
Indomethacin
|
a)
It is a polyene macrolide
antibiotic
|
F
|
|
b)
It is the drug of choice to treat fungal
infection
|
F
|
|
c)
The therapeutic index of
indomethacin is very narrow
|
F
|
|
d)
It is potent anti inflammatory
and weak analgesic
|
T
|
9.
Naproxen
|
a)
It is used to treat rheumatic
fever
|
T
|
|
b)
It is use to treat dysmenorrhea
|
T
|
|
c)
It is higly hepatotoxic drug
|
F
|
|
d)
It acetylate the cyclooxygenase
|
F
|
10.
Calecoxib
|
a)
Selective inhibition of COX2
than COX1
|
T
|
|
b)
It is easily absorb through GI
tract
|
T
|
|
c)
It cause less GI bleeding
|
T
|
|
d)
It gives anticoagulant effect
|
F
|
11.
Higher dose of this drugs can
cause tinnitus.vertigo,hyperventilationand respiratory alkalosis.
|
a)
Ketoconazole
|
F
|
|
b)
Metothrexate
|
F
|
|
c)
Aspirin
|
T
|
|
d)
Paracetamol
|
F
|
12.
It gives depression of respiratory
center and cardiovascular center and lead to low blood pressure
|
a)
Aspirin
|
T
|
|
b)
Ibuprofen
|
F
|
|
c)
Terbinafine
|
F
|
|
d)
Corticosteroid
|
F
|
13.
Aspirin
|
a)
Prophylaxis of disease due to
platelet aggregation
|
T
|
|
b)
Inhibit squaline epoxidase
|
F
|
|
c)
Prevent the sensitization of
pain receptor
|
T
|
|
d)
Inhibition of prostacyclin
|
F
|
14.
These are selective COX-2
inhibitors
|
a)
Calecoxib
|
T
|
|
b)
Acetaminophen
|
T
|
|
c)
Rofecoxib
|
T
|
|
d)
Flurbiprofen
|
F
|
15.
Prostaglandin
|
a)
Gives motility to uterus
|
T
|
|
b)
Increase blood flow in kidney
|
T
|
|
c)
Stimulate platelet aggregation
|
F
|
|
d)
Gives vasoconstriction
|
F
|
16.
Prostacyclin
|
a)
Decrease blood flow in the
kidney
|
F
|
|
b)
Vasodilation
|
T
|
|
c)
Increase vascular permeability
|
F
|
|
d)
Inhibit platelet aggregation
|
T
|
17.
Thromboxane
|
a)
Bronchio constriction
|
F
|
|
b)
Stimulate platelet aggregation
|
T
|
|
c)
Easily absorb in GI tract
|
F
|
|
d)
Vasoconstriction
|
T
|
18.
Very high dose of aspirin can
cause
|
a)
Metabolic acidosis
|
T
|
|
b)
Hyperthermia
|
T
|
|
c)
Dehydration
|
T
|
|
d)
Hypotension
|
F
|
19.
To enhance excretion of aspirin (toxicity),
the treatments that can be use are…
|
a)
Alkalinize urine
|
T
|
|
b)
Activated charcoal
|
F
|
|
c)
Hemodialysis
|
T
|
|
d)
Administer bicarbonate
|
F
|
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