1. Factors
causing fungal infections include AIDS, chronic diseases, broad-spectrum
antibiotics, damaged skin and moist skin (T)
2. Amphotericin
B, Fluconazole, Ketoconazole, Itraconazole and Flucytosine are drugs to treat
cutaneous mycoses. (F)
3. Nystatin
acts by binding to ergosterol (T)
4. Amphotericin
B
a)
|
Amphotericin B is produced by Streptomyces nodosus.
|
T
|
b)
|
Does not affect mammalian cell
membranes because the drug binds to ergosterol rather than cholestrol.
|
T
|
c)
|
Can be safely used for renal
failure patients
|
F
|
5. Ketoconazole
a)
|
First line drug to treat
mucocutaneous candidiasis
|
F
|
b)
|
Should not be given along with
antacids, H2-receptor blockers, proton-pump inhibitors or Amphotericin B
|
T
|
c)
|
Can be given to pregnant woman
|
F
|
d)
|
Ketoconazole decreases androgen
production
|
T
|
6. Fluconazole
a)
|
Is the drug of choice for
cryptococcosis caused by cryptococcus neoformans
|
T
|
b)
|
Eliminated through renal route
|
T
|
c)
|
Does not inhibit CYP450 system
responsible for the synthesis of androgens
|
T
|
6. Itraconazole
a)
|
Has endocrinologic side effects
like ketoconazole
|
F
|
b)
|
Drug of choice for treatment
of Paracoccidiodimycosis,
Blastomycosis, Sporotrichosis, Aspergillosis and Histoplasmosis
|
T
|
c)
|
Major metabolite is
Hydroxy-itraconazole
|
T
|
7. Terbinafine
a)
|
Most often results in
hepatotoxicity and neutropenia
|
F
|
b)
|
Eliminated through bile route
|
F
|
c)
|
Decrease the synthesis of
ergosterol by inhibiting fungal squaline epoxidase
|
T
|
8. Griseofulvine
a)
|
A fungicidal drug
|
F
|
b)
|
Given topically to treat
dermatophytic infection
|
T
|
9. Flucytosine
a)
|
Converted to 5-FdUMP to inhibit
thymidylate kinase
|
F
|
b)
|
Works poorly with Amphotericin B
|
F
|
c)
|
Metabolized in liver
|
T
|
d)
|
5-FdUMP is incorporated in fungal
RNA
|
F
|
No comments:
Post a Comment